Page 126 - Livre électronique des RFTP 2025

P71. CLINICAL AND FUNCTIONAL PATTERNS ACROSS

INTERSTITIAL LUNG DISEASE SUBTYPES

CHAIMA BRIKI¹⁻², KHOULOUD KCHAOU¹⁻², NOUR BEN MRAD¹, SOUMAYA KHALDI¹⁻²,
SALOUA BEN KHAMSA JAMELEDDINE¹⁻²

¹ DEPARTMENT OF PHYSIOLOGY AND FUNCTIONAL EXPLORATIONS, ABDERRAHMENE MAMI
HOSPITAL, ARIANA
² LABORATORY OF PHYSIOLOGY, NUTRITION, AND BIOMOLECULES (LR-17-ES-03), BIOTECHNOLOGY
CENTER OF SIDI THABET, UNIVERSITY OF MANOUBA, TUNIS

Background : Interstitial Lung Diseases (ILDs) represent a heterogeneous group of

conditions with variable clinical presentations and respiratory function profiles.
Exploring these variations across subtypes may support better phenotypic
understanding and tailored management.

Objective : To characterize the clinical and functional profiles of different ILD
subtypes.

Methods : A retrospective study was conducted on 108 patients with ILD, classified
as Idiopathic Pulmonary Fibrosis (IPF), sarcoidosis, hypersensitivity pneumonitis or
connective tissue disease-associated ILD. Collected data included demographics,
smoking status, Body Mass Index (BMI), and respiratory function parameters
(spirometry, DLCO, and six-minute walk test [6MWT]). Dyspnea severity was
assessed using the modified Medical Research Council (mMRC) scale, with scores
≥3 considered severe.

Results : The mean age was 56.4 ± 11.7 years and mean BMI 30.3 ± 7.0 kg/m ².
Smoking was more frequent in IPF (48.7%) than in sarcoidosis (19.3%) (p=0.031), while
obesity was most common in sarcoidosis (59.6%) compared to IPF (43.6%) and
connective tissue ILD (42.9%). Severe dyspnea was reported in 20.5% of IPF, 19.3% of
sarcoidosis, and was not observed in connective tissue-related ILD.

A Restrictive Ventilatory Defect was observed in 46.2% of IPF and 28.1% of
sarcoidosis, whereas Non-Specific Patterns (NSP) were more common in
sarcoidosis (10.5%). Mixed ventilatory patterns appeared only in sarcoidosis (3.5%).
Reduced DLCO was frequent across groups: 68.4% in IPF, 57.1% in sarcoidosis, and
71.4% in connective tissue-related ILD. Pathological 6-minute walk distance was

found in 33.3% of IPF, 14.0% of sarcoidosis, and 42.9% of hypersensitivity pneumonitis
(p=0.018). Desaturation during 6MWT occurred in 38.1% of IPF, 28.2% of sarcoidosis,
and none of the connective tissue-related ILD group.

Conclusion : Clinical and functional differences across ILD subtypes highlight the
need for etiology-based assessment. IPF showed more impairment, while
sarcoidosis presented milder functional impact despite frequent obesity and NSP.

124 | Pa g e